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Despite the fact that man is separated from God, the Bible says very little about it, mostly because the writers of the Bible assume it to be so since the separation of God and man at the very beginning of the Book (Genesis 3:22-24). Everyone who reads the Bible with any kind of understanding recognizes that man and God are not on the same wavelength. They are estranged from one another. Despite so little being written about the separation, a great deal is written about how the two will be reconciled.
Isaiah 59:1-2 is one of the very few places that actually clearly states why the separation exists: because of man's hostility toward God. Paul states in Romans 8:7 that the carnal mind is enmity, hostile, against God, and that hostility, he writes in Ephesians 2:2, is motivated by "the prince of the power of the air." Satan has deceived all of mankind (Revelation 12:9).
John W. Ritenbaugh
Fall Feast Lessons