Commentaries:
Jamieson, Fausset, and Brown
destroy—literally, "grind" or "crush" (Isaiah 3:15).
let loose his hand—God had put forth His hand only so far as to wound the surface of Job's flesh (Job 1:12; Job 2:6); he wishes that hand to be let loose, so as to wound deeply and vitally.
cut me off—metaphor from a weaver cutting off the web, when finished, from the thrum fastening it to the loom (Isaiah 38:12).
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