In chapter 46 this one happened to Jacob, but this one in a way reflects back on Isaac because in the earlier part of chapter 26 Isaac was in a quandary about what to do about something and he was thinking about going down to Egypt and God stopped him from going there. We know what happened to Abraham there. God let him go down there and he got into a bushel of trouble. But in this case God intervened and He stopped Isaac from going there and He reoriented him and said, Instead go to Beersheba, which is where he went. And there He appeared to him to reassure him that he had done the right thing.
Jacob was on his way to meet with Joseph and I am sure that he had second thoughts about going there because he knew what happened to Isaac when he went there and he knew what kind of a land Egypt was and he was not all that sure that was a good move for him to go there. It is interesting that he went to Beersheba apparently because he felt that there would be some contact with God in that place, and sure enough God appeared to him in a vision.
There is a similar call of Jacob. Jacob had started down to Egypt to see Joseph, but he had paused at Beersheba, being fearful of what might lie ahead.
God reassured him: “Jacob! Jacob!” “Here I am,” he replied. This revelation was all Jacob needed. The next verses picture him going on his way confidently and we do not read of his being fearful ever again.