The last two references—the one in Exodus 1, combined with this one in Psalm 105—imply something more than emotional pain, such as slavery or being in jail, but something that physically hurt, as well as psychologically.
If you look in Strong's Concordance at 6031, you will find him using such forceful and painful words to describe it as "browbeat," "deal hardly with," "defile," "force," and "ravish," among others. It is a strong word that will sometimes be translated into forms of "humble."
