The psalmist does not really want to flee. He is posing ideas and questions so that we can see that wherever we are, we are always under God's scrutiny. God is a positive spirit. Everything that He creates has positive function and beauty. His intention in everything for us is always positive, right, and good. He does everything in love and concern for our well-being so that we will fit within His purpose, and it will be worked out in our lives. Psalms 139 contains no negative connotations.
From this, because His mind permeates the entirety of His creation, we ought to derive great confidence that God is always with us. He is omnipotent. He is omnipresent. He is actively using His powers, His Spirit, to govern and manage His creation.
The beginning of the source of all power is in the mind. Remember, man is in God's image. A man may make tools to intensify his powers, but the real power is in the mind because without it, he would not be able to create the tool that expands his powers.
God's Holy Spirit is the essence of His mind. Just like a man, His power resides there too, only He does not have to use steam shovels and power tools to get things done. He speaks, and the laws He has created go to work. The tool by which He carries everything out is His Spirit, the essence of His mind.
John W. Ritenbaugh
The Right Use of Power
The Holy Spirit is the power of God. It is the means through which He accomplishes His will. Verse 7 teaches us a great deal about this. God the Father is a Personality. He is located in one place at one time, just as we are. But His ability to insert Himself into and affect events anywhere in His creation is contained within the power that emanates from His mind.
It is His Spirit—which emanates from His mind—that enables Him to be everywhere all at once, if He so desires. It gives Him the ability to keep track of all of us. It gives Him the ability to be with a person in Charlotte or someone in Los Angeles or another in Chicago. Wherever we are, He can be there because by His mind He is able to concentrate His attention in those areas.
We lack power like that. We have limited imitations of it. We can concentrate our attention in a very limited way on certain things, events, or places. But He can concentrate His attention in many areas at the same time by the spiritual power that emanates from His awesome mind.
John W. Ritenbaugh
The Holy Spirit
Omnipresence is an eternal attribute of God. He is omnipresent through His Holy Spirit, the same boundless power that provides for His omnipotence (Jeremiah 32:17; Zechariah 4:6).
David understood and made the connection between God's presence and His Holy Spirit. “Do not cast me away from Your presence, and do not take Your Holy Spirit from me” (Psalm 51:11). Because God is everywhere, He sees and hears us—just as He saw and heard David—personally (John 2:24-25). He is always present in all places through His Spirit. God is never confined but is present in all His power at every point in space and time. David addressed this attribute directly when he asked: “Where can I go from Your Spirit? Or where can I flee from Your presence?” (Psalm 139:7).
Martin G. Collins
God's Non-Transmittable Attributes (Part Two): Omnipresence
Other Forerunner Commentary entries containing Psalms 139:7:
1 John 5:14-15