Put this together with what Paul has already said. Everybody, all those who have not been called, are under the penalty of death. They are the carnal-minded. And even those of us who have been called still have carnal minds that we need to improve or actually Paul tells us to kill it. Mortify the flesh, mortify all those urgings of human nature to be selfish and to turn against God's way. So from Adam's day to this very second, people have sinned, early and often. In sinning, they have become guilty and subject to death and the wrath of a just and righteous God.
Even one sin—just one sin!—puts us on the negative side of the ledger. One sin and we might as well just do the perp walk because we are guilty. What is worse, one sin makes us enemies of God because we have given in to the enmity of the carnal mind against God. One sin and we are in rebellion. And He can come down on us with His wrath anytime He chooses, and we have no recourse because we are guilty.
So, humanity has a rebellious nature against God and His law to the point that man, as it says here in Romans 8:7, man cannot be subject to God or His law, neither indeed can be. That is astounding! Carnal humans cannot do the things that please God. Because they are full of sin it taints everything they do. In fact, even if they have a desire to square the debt of sin with God, humans can do nothing to correct the situation. Not a single thing can they do to get on the good side of the ledger. They owe a debt they cannot pay.