Commentaries:
Jamieson, Fausset, and Brown
Lord of peace—Jesus Christ. The same title is given to Him as to the Father, "the GOD of peace" (Romans 15:33; Romans 16:20; II Corinthians 13:11). An appropriate title in the prayer here, where the harmony of the Christian community was liable to interruption from the "disorderly." The Greek article requires the translation, "Give you the peace" which it is "His to give." "Peace" outward and inward, here and hereafter (Romans 14:17).
always—unbroken, not changing with outward circumstances.
by all means—Greek, "in every way." Most of the oldest manuscripts read, "in every place"; thus he prays for their peace in all times ("always") and places.
Lord be with you all—May He bless you not only with peace, but also with His presence (Matthew 28:20). Even the disorderly brethren (compare II Thessalonians 3:15, "a brother") are included in this prayer.
Other Jamieson, Fausset, and Brown entries containing 2 Thessalonians 3:16:
Romans 15:33
1 Thessalonians 3:11
Hebrews 13:20
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