Commentaries:
Jamieson, Fausset, and Brown
Flee—There are many lusts from which our greatest safety is in flight (Genesis 39:12). Avoid occasions of sin. From the abstemious character of Timothy (I Timothy 5:23) it is likely that not animal indulgences, but the impetuosity, rash self-confidence, hastiness, strife, and vainglory of young men (I John 2:14-16), are what he is here warned against: though the Spirit probably intended the warning to include both in its application to the Church in general.
also—Greek, "But"; in contrast to "every good work," II Timothy 2:21.
youthful—Timothy was a youth (I Timothy 4:12).
righteousness—the opposite of "iniquity," that is, unrighteousness (II Timothy 2:19; compare I Timothy 6:11).
peace, with, etc.—rather, put no comma, "peace with them that call on the Lord out of a pure heart" (I Timothy 1:5; Ephesians 6:5; Colossians 3:22). We are to love all men, but it is not possible to be at peace with all men, for this needs community of purpose and opinion; they alone who call on the Lord sincerely (as contrasted with the false teachers who had only the form of godliness, II Timothy 3:5, II Timothy 3:8; Titus 1:15-16) have this community [THEODORET]. (Romans 12:18).
Other Jamieson, Fausset, and Brown entries containing 2 Timothy 2:22:
Romans 10:12
1 Corinthians 1:2
Philippians 2:10
1 Timothy 1:5
1 Timothy 4:7
1 Timothy 4:12
1 Timothy 6:11
1 Timothy 6:20-21
2 Timothy 1:6
2 Timothy 1:7
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