Commentaries:
Adam Clarke
In Isaac shall thy seed be called - Here God shows the propriety of attending to the counsel of Sarah; and lest Abraham, in whose eyes the thing was grievous, should feel distressed on the occasion, God renews his promises to Ishmael and his posterity.
Other Adam Clarke entries containing Genesis 21:12:
Genesis 22:5
2 Samuel 17:17
2 Kings 2:23
John 8:35
Romans 9:7
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