The meaning of Mesopotamia in the Bible
(From Easton's Bible Dictionary)
the country between the two rivers (Heb. Aram-naharaim; i.e., "Syria of the two rivers"), the name given by the Greeks and Romans to the region between the Euphrates and the Tigris (Genesis 24:10; Deuteronomy 23:4; Judges 3:8,10). In the Old Testament it is mentioned also under the name "Padan-aram;" i.e., the plain of Aram, or Syria (Genesis 25:20). The northern portion of this fertile plateau was the original home of the ancestors of the Hebrews (Genesis 11; Acts 7:2). From this region Isaac obtained his wife Rebecca (Genesis 24:10,15), and here also Jacob sojourned (28:2-7) and obtained his wives, and here most of his sons were born (35:26; 46:15). The petty, independent tribes of this region, each under its own prince, were warlike, and used chariots in battle. They maintained their independence till after the time of David, when they fell under the dominion of Assyria, and were absorbed into the empire (II Kings 19:13).
See more on the meaning of Mesopotamia in the Bible:
Mesopotamia {International Standard Bible Encyclopedia}
Mesopotamia {Hitchcock's Bible Name}
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