The meaning of Syria in the Bible
(From Easton's Bible Dictionary)
(Heb. Aram), the name in the Old Testament given to the whole country which lay to the north-east of Phoenicia, extending to beyond the Euphrates and the Tigris. Mesopotamia is called (Genesis 24:10; Deuteronomy 23:4) Aram-naharain (=Syria of the two rivers), also Padan-aram (Genesis 25:20). Other portions of Syria were also known by separate names, as Aram-maahah (I Chronicles 19:6), Aram-beth-rehob (II Samuel 10:6), Aram-zobah (II Samuel 10:6,8). All these separate little kingdoms afterwards became subject to Damascus. In the time of the Romans, Syria included also a part of Palestine and Asia Minor.
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