The meaning of Despair in the Bible
(From International Standard Bible Encyclopedia)
de-spar': The substantive only in II Corinthians 4:8, "perplexed, but not in (the Revised Version (British and American) "yet not unto") despair," literally, "being at a loss, but not utterly at a loss." "Unto despair" here conveys the force of the Greek prefix ex ("utterly," "out and out"). Desperate, in Job 6:26; Isaiah 17:11. In the latter instance, the Hebrew adjective is derived from a verb = "to be sick," and the literally, rendering would be "incurable" (compare Job 34:6, "my wound is incurable"). Desperately in Jeremiah 17:9 the King James Version, where the heart is said to be "desperately (i.e. incurably) wicked" or "sick."
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