Paul uses these phrases as an overall assessment of the cause of the horrible conduct he describes. The root cause is that a true relationship with God is missing. Despite having some knowledge of God, people are not living by faith. They are ignoring Him and feel free to pursue their own desires, on which they place a higher priority than on what God says. Their pleasure is what they desire in terms of conduct, and the behaviors that Paul lists reveal the lack of godly fear. He is simply not an all-the-time reality to them.
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