We can interpret this two ways. First, from the beginning of God's dealings with mankind, He shows a major objective for man is to be accomplished by overcoming, mastering sin's desire to control and manipulate. Sin's desire is always lurking within man's moral and ethical choices, and he needs to be aware of it and have the drive to conquer it.
Second, it is a warning contained in a prophecy to all but given specifically to Cain. God perceived in him a strong proclivity to sin, so much that he would become a master of it. In today's parlance, Cain would become a real "pro" at sinning. The warning is not to allow oneself to follow Cain's example, which gives the impression that he nurtured sin dwelling in him.
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