Commentaries:
The inference is obvious. Moses gave this instruction so that the Israelites would not work on the Sabbath day. The first commandment that God specifically revealed to His people after coming out of Egypt was the Sabbath, the commandment most important for keeping people free. If people miss their weekly appointment with God because they have something else going, then they are missing the opportunity to remain free, squandering the time that God has given to mankind to help them to enter His Kingdom. The Sabbath is a wonderful gift He has given to us.
John W. Ritenbaugh
The Fourth Commandment (Part 1)
Other Forerunner Commentary entries containing Exodus 16:22:
Exodus 16:16-18
Exodus 31:12-17