The concept of self-denial is at the heart of Paul's teaching on submission to God: We have died with Christ and must sacrifice our lives for Him. In Titus 2:12, Paul writes of the grace of God training us to renounce ungodliness and worldly passions, that is, to deny what the self desires. Self-denial requires genuine humility in submission, or it is merely a counterfeit.
Martin G. Collins
Overcoming (Part 5): Self-Denial
"On this one will I look" in Isaiah 66:2 means "I will pay attention to this person." It is another way of saying He will draw closer to such a man or woman. James 4:6-8, 10 reinforces the importance of humility in our relationship with God. Why is humility so important? It plays a major role in producing obedience and thus a good relationship with God. Put another way, humility manifests itself in obedience. It is the attitude of ready submission to God's will, as well as an expression of dependence upon Him. This quality of character is essential to growth, witnessing for God, glorifying God, receiving honor from God and salvation itself. The Bible reveals an order to these things: humility, submission, obedience, and honor (I Peter 5:5-6).
John W. Ritenbaugh
The Sovereignty of God: Part Nine
Other Forerunner Commentary entries containing James 4:10: