Psalm 22:1
The psalm begins with perhaps the most heart-rending cry in history: "My God, My God, why have You forsaken Me?" (Psalm 22:1). As Matthew and Mark attest, Jesus Himself spoke these words as He was about to die: "And about the ninth hour [mid-afternoon] Jesus cried out with a loud voice, saying, 'Eli, Eli, lama sabachthani?' that is, 'My God, My God, why have You forsaken Me?" (Matthew 27:46; see also Mark 15:34).
Our Savior's cry of abandonment marks His awareness that His Father had indeed turned from Him, being burdened and defiled by all human sin (Isaiah 53:6; II Corinthians 5:21; Hebrews 2:9). As Isaiah 59:2 informs us, "But your iniquities have separated you from your God; and your sins have hidden His face from you, so that He will not hear." Because He had never been sinful, Jesus had never known separation from the Father, and His feeling of desertion and rejection may have been the deepest cut of all.
Richard T. Ritenbaugh
David the Prophet

Psalm 22 stands as one of David's most clearly prophetic psalms, so vivid in its depiction of crucifixion that its writer seems present at the Cross. Written roughly a thousand years before Christ, and centuries before the Romans made crucifixion a prominent form of execution, it can only be a divinely inspired prophecy of the Son of God's death. Its opening cry, quoted by Jesus as He died ("Eli, Eli, lama sabachthani," Matthew 27:46; Mark 15:34), marks His awareness that His Father had turned from Him. Burdened and defiled by all human sin, Jesus experienced the separation that iniquity brings (Isaiah 59:2). Having never sinned, He had never known such abandonment, and this rejection may have been the deepest cut of all.