10 And Abraham stretched out his hand and took the knife to slay his son.
11 But the aAngel of the Lord called to him from heaven and said, “Abraham, Abraham!” So he said, “Here I am.”
12 And He said, a“Do not lay your hand on the lad, or do anything to him; for bnow I know that you fear God, since you have not cwithheld your son, your only son, from Me.”
13 Then Abraham lifted his eyes and looked, and there behind himwas a ram caught in a thicket by its horns. So Abraham went and took the ram, and offered it up for a burnt offering instead of his son.
14 And Abraham called the name of the place,1 The-Lord-Will-Provide; as it is said to this day, “In the Mount of the Lord it shall be provided.”
15 Then the Angel of the Lord called to Abraham a second time out of heaven,
16 and said: a“By Myself I have sworn, says the Lord, because you have done this thing, and have not withheld your son, your only son—
God is assured that He has first place in the heart of his servant Abraham. Again, notice the tenderness in the words. He calls Isaac "your son, your only son," thinking no doubt of His own relationship with His Father.
God laid His hands on Egypt in divine judgment by sending plagues. When trying a blasphemer, each witness placed his hands upon the guilty person to signify his acceptance of the verdict. Conversely, when a victim was spared death—as when God commanded Abraham not to sacrifice Isaac or when He allowed the leaders of Israel to see Him without dying—mercy is described as hands not being laid on the spared victim.