The meaning of Nazarene in the Bible
(From Easton's Bible Dictionary)

This epithet (Gr. Nazaraios) is applied to Christ only once (Matthew 2:23). In all other cases the word is rendered "of Nazareth" (Mark 1:24; 10:47; 14:67, etc.). When this Greek designation was at first applied to our Lord, it was meant simply to denote the place of his residence. In course of time the word became a term of reproach. Thus the word "Nazarene" carries with it an allusion to those prophecies which speak of Christ as "despised of men" (Isaiah 53:3). Some, however, think that in this name there is an allusion to the Hebrew netser , which signifies a branch or sprout. It is so applied to the Messiah (Isaiah 11:1), i.e., he whom the prophets called the Netse , the "Branch."

See more on the meaning of Nazarene in the Bible:
Nazarene {International Standard Bible Encyclopedia}

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