This begins a long section of instruction regarding adultery and harlotry. The first warning is to protect one's heart—not one's body—from her because the body follows the heart's lusts. Since Babylon, the Great Whore, is our spiritual temptation, this is a veiled admonition to steer clear of Babylon. Verse 26 reveals her predatory nature; she preys upon the precious lives of her victims like a cat preys on birds. Satan, the father of Babylon and its ways, "walks about like a roaring lion, seeking whom he may devour" (I Peter 5:8).
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