Commentaries:
We can learn much of Jesus' submission to the Father from His prayer in the Garden of Gethsemane just before His crucifixion. This comes from the heart of a man described as meek and lowly of heart. His words paint a vivid picture of what was going through His mind. Sometime during His life, He had likely witnessed a crucifixion, but even if He had not, He certainly had heard one described. As quick of mind as He was, He could clearly envision what lay before Him. Undoubtedly, He anticipated great bodily pain, understanding Isaiah 52:14 to predict He would suffer pain as nobody else ever had. In addition, He had to bear the pressure of resisting the urge to break faith and sin under the burden of the guilt of all mankind's sins that would come upon Him.
He also knew He would have the embarrassment of all the indignities heaped upon Him, knowing full well He was innocent. He had to battle demons throughout His ordeal. Perhaps the most dreaded burden of all was knowing that He would be cut off from God and have to bear everything alone. Yet He did it! Jesus—by faith—consciously chose to submit to the Father based on His knowledge of the Most High.
John W. Ritenbaugh
Sovereignty and Its Fruit: Part Ten
Matthew, Mark, and Luke each record Christ praying to the Father on this fateful night, asking if He might “let this cup pass from Me.” He mentions the same “cup” in rebuking Peter's assault on Malchus: “So Jesus said to Peter, 'Put your sword into the sheath. Shall I not drink the cup which My Father has given Me?'” (John 18:11).
The image of drinking from a cup is a metaphor for His submission to the Father's will, while the cup itself stands for the enormous burden His submission would require (Luke 22:42-44). Despite desiring that some other way could be found to accomplish the payment for mankind's sins, Jesus bowed to His Father's will in the matter and gave Himself up to the arresting troops.
Martin G. Collins
The Miracles of Jesus Christ: Healing Malchus' Ear (Part Two)
Other Forerunner Commentary entries containing Luke 22:42:
Matthew 26:39
Mark 13:37
Colossians :
1 Thessalonians 5:18
James 5:15-16